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Lion Tracks Lion Track icon Lion Den » A&P » AP1 Lec » Extra Credit » Genome

Genome

An "extra credit" opportunity

family tree

Part 1

Part 2

Part 3

Part 4

Part 5

The human genome is currently the focus of intense research around the world.  We are finding many applications for genomic research in physiology --and more are found every day.  For that reason, to understand modern anatomy & physiology one must also understand the basics of the human genome.

This activity is divided into several parts to make it easier.  Each part requires some reading in the book Genome:The Autobiography of a Species in 23 Chapters by Matt Ridley. 2000. Perennial. (available as hardcover or  paperback). This book is organized by "chromosome number" rather than by "chapter number" so pay attention to the assignments below.  Review questions to help you study are included in the separate page called Genome Questions.

There is a separate online lab quiz on WebCT for each part of the Genome Lab. 

November 15 is the deadline for Extra Credit activities.

Want to take a short break for a song?
How about Jonathon Coulton's song That Spells DNA
(lyrics)

Part 1

1. Read the Introduction to the Genome book. Use the appropriate review questions to assist your learning.

2. Watch the PBS Nova program Cracking the Code of Life

To view it online click here

liontrackIf  you are having trouble with viewing online, try:

  • If you have a slow connection, wait a while for the file to download and try to play it again (this usually works)

  • Make sure you have Quicktime or RealPlayer installed

  • Use a faster internet connection
    • Go to Advanced Options page at Nova site and select a smaller file size version
    • Use a campus machine (make sure you request a headphone)

  • Try Technical Help page at the Nova site

  • Borrow or purchase a copy of the VHS or DVD version (check campus library for interlibrary loans)

Use the following outline of the film's 16 "chapters" to help you remember what you learn. I suggest printing it out and taking notes as you watch (or cut-&-pasting it into your word processor, open in a second window as you watch each clip, and typing your notes into the outline).  If you don't take notes, you won't remember enough detail to answers the quiz . . . and you'll have to rewatch it.  See also the hint that follows the outline.

Cracking the Code of Life

1. Instructions for a Human Being                                               

a storybook
4 billion years of history
DNA -- the secret of life

running time 09:06

2. Getting the Letters Out

the Human Genome Project
1000 letters a second
a parts list

running time 05:52

3. One Wrong Letter

Tay Sachs
an incurable disease
carriers for rare condition

running time 08:57

4. The Sequencing Race Begins

Craig Venter
machines that go fast
Celera Genomics

running time 06:29

5. Ramping up

government teams respond
the bleeding edge
a public investment

running time 07:48

6. Genetic Variation

whose code is it?
remarkably similar
sharing genes with a banana

running time 06:33

7. Who Owns the Genome?

making history
patenting genomic code
drug companies

running time 07:52

8. The Business of Science

profiting from the genome
Celera's buisiness plan
change in the scientific community

running time 04:06

9. Finding Cures is Hard

cystic fibrosis
from genes to proteins
3-dimensional shapes

running time 08:07

10. Complexity in Proteins

an atypical CF patient
the proteome
twice as many genes as a fruit fly

running time 07:44

11. The Finish Line

all 3 billion letters
pressure of competition
a new beginning in science

running time 04:32

12. Finding Disease Genes

bald guys
Iceland -- all in the family
DeCODE's giant DNA database

running time 04:06

13. DNA Databases

future diary
GATTACA
gene chips

running time 04:14

14. A Family Disease

ovarian and breast cancer
BRCA mutations
50/50 chance

running time 08:05

15. Genetic Modification

enhancing your kids?
genetically modified foods
a complex machine

running time 04:27

16. Contemplating the Message

sharing the credit
a lumpy genome
connectedness of life

running time 07:58

lion trackHINT:   If you want to, you can print out the transcript to highlight or to take notes as you view each segment of the film --or as a review of its contents.

When you are finished with Part 1, take the online test Genome 1 on WebCT

 

Part 2

1. Read about Chromosomes 1 through 4 in the book Genome.

2. Use the appropriate review questions to assist your learning.

3. After reading assigned passages, click here to see the "big picture" of DNA and its relationship to your body and its function.  Make sure that you become familiar with these concepts (some you will find in the book, some in the online activity, some may need a little research on the web or in the library):

DNA                                                                                                               

double helix

chromatin

nucleotide

base pair

mRNA

tRNA

rRNA

nucleosome

codon

gene

chromosome

genome

genomics

proteome

proteomics

 

When you are finished with Part 2, take the online test Genome 2 on WebCT

 

Part 3

1. Read about Chromosomes 5 through 9 in the book Genome

2. Use the appropriate review questions to assist your learning.

3. After reading the assigned passages, click here to explore some code from the human genome.  Make sure that you become familiar with these concepts (some you will find in the book, some in the online activity, some need a little research on the web or in the library):

intron                                                                                                                 

exon

start codon

stop codon

hitchhiking code

ancient code

on/off switch

sites of variation

 

When you are finished with Part 3, take the online test Genome 3 on WebCT

 

Part 4

Read about Chromosomes 10 through 17 in the book Genome.

Use the appropriate review questions to assist your learning.

When you are finished with Part 4, take the online test Genome 4 on WebCT

 

Part 5

Read about Chromosomes 18 through 22 in Genome

Use the appropriate review questions to assist your learning.

When you are finished with Part 5, take the online test Genome 5 on WebCT

 

 

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This page updated on 7-sep-10